KHÓA CHỐNG TRỘM XE MÁY, KHÓA CHỐNG TRỘM XE TAY GA LÀ MỘT TRONG NHỮNG DỊCH VỤ VÀ SẢN PHẨM CHÍNH TẠI KHẢI HOÀN. LIÊN HỆ VỚI CHÚNG TÔI ĐỂ ĐƯỢC TƯ VẤN TỐT NHẤT
Thứ Ba, 1 tháng 1, 2013
Settlement Reached in Toyota Acceleration Cases
Tour Bus Crash Kills 9 in Oregon
With a Parent at War, a Holiday of Pain and Pride
Toyota to Settle Class-Action Suits Over Sudden Accelerations
Occupy Movement Was Investigated by F.B.I. Counterterrorism Agents, Records Show
Russia Urges Assad to Negotiate with His Opponents
Ellen Barry reported from Moscow, and Kareem Fahim from Beirut, Lebanon.
In Shift, Israel Lets Building Materials Into Gaza
An employee of The New York Times contributed reporting from Gaza.
Critic’s Notebook: Reality Shows Reached for Extremes in 2012
N.Y.U. and Others Offer Shorter Courses Through Medical School
Raid on Kenyan Village Said to Leave 30 Dead
ArtsBeat: ‘The Hobbit’ Stays No. 1 at the Box Office
The weekend before Christmas is typically a weird one for Hollywood. It is one of the only periods all year when a movie’s performance over its first three days does not necessarily signal how good (or bad) total ticket sales will be; ticket buyers may still materialize in significant numbers over the holiday week.
“The Hobbit: An Unexpected Journey,” distributed by Warner Brothers, was No. 1 at North American theaters over the weekend, taking in about $36.7 million, for a two-week total of $149.9 million, according to Hollywood.com, which compiles box-office data. Placing second was “Jack Reacher,” which overcame prerelease troubles — Paramount canceled promotional events after the Connecticut school massacre — to sell about $15.6 million in tickets; “Jack Reacher,” which cost roughly $60 million to make, received an A-minus score from audiences in exit polls, boding well for word of mouth.
Judd Apatow’s heavily marketed comedy “This Is 40” (Universal) was third, taking in about $12 million. That total was in line with expectations, and Universal deemed it “good.” But audiences gave Mr. Apatow’s weakly reviewed movie a B-minus in exit polls, indicating a rough road ahead. But it cost a relatively inexpensive $35 million to make.
DreamWorks Animation’s “Rise of the Guardians” was fourth, taking in about $5.9 million, for a five-week total of $79.7 million. Steven Spielberg’s “Lincoln” (Disney) continued to chug along, placing fifth, with an estimated $5.6 million in ticket sales, for a seven-week total of $116.8 million.
U.S. Civilian Is Killed at Police Headquarters in Kabul
Obama Blames ‘Sloppiness’ for Benghazi Attack
Real Estate Market Along Coast Upended by Hurricane
Cara Buckley contributed reporting.
Victim of Gang Rape in India Dies at Hospital in Singapore
Niharika Mandhana contributed reporting from New Delhi, and Keith Bradsher contributed from Hong Kong..
Is the Cure for Cancer Inside You?
Ralph Steinman in 1983. He would become his most compelling experiment.
The cell Steinman hoped would save his life looks something like a sea anemone or a ruffled shrimp dumpling. The Nobel Foundation doesn’t allow posthumous awards, so when news of Ralph Steinman’s death reached Stockholm a few hours later, a minor intrigue ensued over whether the committee would have to rescind the prize. It would not, in fact; but while newspapers stressed the medal mishap (“Nobel jury left red-faced by death of laureate”), they spent less time on the strange story behind the gaffe. That Steinman’s eligibility was even in question, that he’d been dead for just three days instead of, say, three years, was itself a minor miracle. In the spring of 2007, Steinman, a 64-year-old senior physician and research immunologist at Rockefeller University in New York, had come home from a ski trip with a bad case of diarrhea, and a few days later he showed up for work with yellow eyes and yellow skin — symptoms of a cancerous mass the size of a kiwi that was growing on the head of his pancreas. Soon he learned that the disease had made its way into nearby lymph nodes. Among patients with his condition, 80 percent are dead within the first year; another 90 percent die the year after that. When he told his children about the tumor over Skype, he said, “Don’t Google it.” But for a man who had spent his life in the laboratory, who brought copies of The New England Journal of Medicine on hiking trips to Vermont and always made sure that family vacations overlapped with scientific symposia, there was only one way to react to such an awful diagnosis — as a scientist. The outlook for pancreatic cancer is so poor, and the established treatments so useless, that any patient who has the disease might as well shoot the moon with new, untested therapies. For Steinman, the prognosis offered the opportunity to run one last experiment. In the long struggle that was to come, Steinman would try anything and everything that might extend his life, but he placed his greatest hope in a field he helped create, one based on discoveries for which he would earn his Nobel Prize. He hoped to reprogram his immune cells to defeat his cancer — to concoct a set of treatments from his body’s own ingredients, which could take over from his chemotherapy and form a customized, dynamic treatment for his disease. These would be as far from off-the-shelf as medicines can get: vaccines designed for the tumor in his gut, made from the products of his plasma, that could only ever work for him. Steinman would be the only patient in this makeshift trial, but the personalized approach for which he would serve as both visionary and guinea pig has implications for the rest of us. It is known as cancer immunotherapy, and its offshoots have just now begun to make their way into the clinic, and treatments have been approved for tumors of the skin and of the prostate. For his last experiment, conducted with no control group, Steinman would try to make his life into a useful anecdote — a test of how the treatments he assembled might be put to work. “Once he got diagnosed with cancer, he really started talking about changing the paradigm of cancer treatment,” his daughter Alexis says. “That’s all he knew how to do. He knew how to be a scientist.” First, Steinman needed to see his tumor. Not an M.R.I. or CT scan, but the material itself. The trouble was that most people with his cancer never have surgery. If there’s cause to think the tumor has spread — and there usually is — it may not be worth the risk of having it removed, along with the bile duct, the gallbladder, large portions of the stomach and the duodenum. Luckily for Steinman, early scans showed that his tumor was a candidate for resection. On the morning of April 3, 2007, less than two weeks after his diagnosis, he went in for the four-hour procedure at Memorial Sloan-Kettering Cancer Center, just across the avenue from his office at Rockefeller University. Potent Storm Hits Wide Swath of U.S. and Moves East
The brunt of the storm was expected to hit western New York and extend into central Maine through Thursday morning, forecasters said, an area that could get 12 to 18 inches of snow. In Buffalo, as much as two inches each hour could be falling by Thursday morning, combined with 30-mile-per-hour winds, according to the Weather Service.
In New York City, the slushy snow that fell initially gave way to heavy rain and sustained wind of up to 35 miles per hour, and gusts as high as 60 miles per hour were expected overnight, said Tim Morrin, Observation Program Leader at the National Weather Service. The heavy rain, up to 1.8 inches overnight, could lead to flooding in areas with poor drainage, Mr. Morrin said. There is a coastal flood warning in effect during high tides Wednesday and early Thursday “along the Battery, Bergen Point, the mouth of the Hudson and portions of the western Long Island Sound,” he added. Flights into Newark and LaGuardia airports were delayed by more than two hours on Wednesday evening, and flights into John F. Kennedy International were held up for over an hour, according to the Federal Aviation Authority. The storm, Mr. Morrin said, is not due to taper off until Thursday afternoon. In Westchester County, where some wires went down after 7 p.m. in Larchmont, 2,300 customers were without electricity on Wednesday evening, said Chris Olert, a spokesman for Con Edison. On Tuesday, parts of the country unaccustomed to a white Christmas were hit hard by snow, including Little Rock, Ark., where nine inches fell, and parts of Oklahoma, where seven inches of snow contributed to a 21-vehicle pileup on an interstate outside Oklahoma City, the authorities said. While that accident caused no serious injuries, a car crash in Major County, in northern Oklahoma, killed a 28-year-old woman as the vehicle she was riding in struck a tractor-trailer on a snowy highway, the Oklahoma Highway Patrol said. Also Tuesday, a man died outside Houston when he got out of his car to remove a tree that had fallen in high winds and blocked the road. As he tried to drag the tree away, a second tree fell and crushed him, according to the Harris County sheriff’s office. More than 200,000 people remained without power on Wednesday, many in Arkansas, where winds toppled power lines and trees. Thirty-four tornadoes were reported from Texas to Mississippi on Tuesday, prompting Gov. Phil Bryant of Mississippi to declare a state of emergency after several counties were battered by storms, including a twister that destroyed homes in Pearl River County, said Danny Manley, the county’s emergency management director. A tornado also rolled through downtown Mobile, Ala., causing significant damage to Murphy High School and tearing off part of the roof of Trinity Episcopal Church, according to the Mobile County Emergency Management Agency. No serious injuries were reported. In California, two people died Monday in avalanches in the Sierra Nevada Mountains, where there was heavy snowfall over the weekend, the authorities said. Ravi Somaiya contributed reporting.Egypt Constitution Passes, Economic Crunch Looms
With a Parent at War, a Holiday of Pain and Pride
At Queens High Rise, Fear, Death and Myth Collided
Alain Delaquérière, Lisa Schwartz and Jack Styczynski contributed research.
Follow Sheri Fink on Twitter: @SheriFink